Belzer MPS: The Ultimate Guide for Perfusion

Belzer MPS is a specifically formulated perfusate designed for in-vitro flushing and continuous hypothermic machine perfusion of kidneys, offering a proven approach to preserving kidney integrity and functionality during transport and storage. This solution minimizes ischemic injury and optimizes organ recovery, with a recommended perfusion time of around 29 hours at 4°C-8°C. Proper storage between 2°C to 25°C and pre-cooling the kidney before perfusion are essential. By understanding the indications, storage guidelines, device description, and precautions, clinicians can guarantee safe and effective use of Belzer MPS. Further insight into its applications and benefits awaits.

Key Takeaways

• Belzer MPS is used for in-vitro flushing and continuous hypothermic machine perfusion of kidneys, preserving integrity and functionality during transport and storage.
• The recommended perfusate volume is 1000 mL for two human kidneys, with a recommended perfusion time of around 29 hours at 4°C-8°C.
• Belzer MPS should be stored between 2°C to 25°C, with an ideal perfusion temperature of 5°C and an acceptable range of 4°C to 8°C.
• The solution contains Hydroxyethyl Starch, Penicillin, Regular Insulin, and other constituents, with optional Dexamethasone, and no adverse reactions observed when used correctly.
• Physicians should be cautious of hypersensitivity reactions, especially with Hydroxyethyl Starch and additives, and manage potential reactions accordingly.

Understanding Belzer MPS Indications

Belzer MPS is specifically intended for in-vitro flushing and continuous hypothermic machine perfusion preservation of explanted kidneys, with a recommended volume of 1000 mL perfusate sufficient for two human kidneys. This solution is designed to preserve the kidneys outside the body, maintaining their integrity and functionality during transport and storage.

The machine perfusion process helps to minimize ischemic injury and optimize organ recovery. The recommended perfusion time is around 29 hours, with a suitable temperature range of 4°C-8°C.

Storage and Preparation Guidelines

Proper storage and preparation of Belzer MPS are vital steps in ensuring the solution's efficacy and safety in kidney preservation. The recommended storage temperature ranges from 2°C to 25°C. The ideal temperature for perfusion is 5°C, with an acceptable range of 4°C to 8°C.

Pre-cooling the kidney with Belzer MPS or other cooled solutions (2°C to 8°C) is essential before perfusion. It is important to inspect the perfusate for particulate matter or contamination before use.

Additionally, the solution should be flushed from the donor organ at the time of implantation. By following these guidelines, clinicians can guarantee excellent performance and safety of Belzer MPS in kidney preservation.

Device Description and Additives

The perfusion solution, a clear to straw-colored liquid, is specifically designed for flushing and temporary continuous perfusion preservation of kidneys, comprising a unique blend of additives and constituents. This solution is formulated to provide excellent kidney preservation during transportation and storage.

It contains Hydroxyethyl Starch, which may cause hypersensitivity reactions in rare cases. Additionally, the solution includes additives such as Penicillin, Regular Insulin, and Dexamethasone (optional), ensuring additive safety. The solution's composition also features various constituents like Adenine, Calcium Chloride, and Dextrose.

Importantly, no adverse reactions have been observed when used as directed. By understanding the components and properties of Belzer MPS, clinicians can confidently use this solution for effective kidney preservation.

Important Precautions and Warnings

When utilizing Belzer MPS, it is important to be mindful of potential hypersensitivity reactions, as well as other important precautions and warnings, to guarantee safe and effective use of the solution.

Hypersensitivity risks are associated with the presence of Hydroxyethyl Starch and additives, such as Penicillin, Regular Insulin, and Dexamethasone. Physicians should be prepared to manage possible hypersensitivity reactions.

Additionally, Belzer MPS is not intended for systemic administration or in situ flushing of organs in living donors. Reuse concerns are also paramount, as reusing the solution can lead to infection or cross-contamination risks.

Therefore, it is essential to use Belzer MPS as directed and follow proper storage and preparation guidelines to ensure best outcomes.

Contact Information and References

Manufactured by Preservation Solutions, Inc. in Elkhorn, WI, and marketed by Bridge to Life Ltd. in Columbia, SC, Belzer MPS is a trademark of the Wisconsin Alumni Research Foundation (WARF). For clinical experience with organ preservation solutions, contact the company for a bibliography. The manufacturer provides valuable resources for perfusionists and clinicians.

For questions or assistance with Belzer MPS, contact the manufacturer directly. Their team is dedicated to providing exceptional support to guarantee successful kidney preservation and transplantation outcomes.

Frequently Asked Questions

Can Belzer MPS Be Used for Organs Other Than Kidneys?

While Belzer MPS is specifically designed for kidney preservation, its use for other organs, such as liver transplants, is not established, and heart preservation requires alternative solutions, emphasizing the importance of organ-specific preservation protocols.

What Is the Maximum Allowed Temperature Deviation During Perfusion?

Importantly, a mere 1°C temperature deviation can greatly impact perfusion outcomes. During perfusion, temperature control is essential, with an acceptable range of 4°C-8°C, ensuring perfusion precision and ideal organ preservation.

Are There Any Specific Disposal Guidelines for Belzer Mps?

Proper handling of Belzer MPS necessitates adherence to regulatory compliance for disposal, ensuring environmentally responsible waste management and minimizing potential risks to humans and the environment, thereby upholding professional standards.

Can Belzer MPS Be Used in Pediatric Kidney Transplants?

In a pediatric kidney transplant case study, Belzer MPS was successfully used for preservation, highlighting the need for pediatric considerations, as age limitations may impact perfusion time and solution composition, warranting careful evaluation.

Is Belzer MPS Compatible With Other Preservation Solutions?

When considering compatibility with other preservation solutions, it is essential to evaluate potential solution interaction and chemical reactions that may affect organ viability, emphasizing the importance of careful assessment to guarantee the best perfusion outcomes.